Congenital cytomegalovirus infection: background for manifestation; clinical case; difficulties of treatment

Congenital CMV is the leading cause of congenital infections in newborns worldwide and can lead to significant morbidity, mortality, or long-term consequences. Purpose — demonstrate results screening for cytomegalovirus infection pregnant women children first months life illustrate a clinical case severe difficulties selecting specific therapy. Materials methods. The article presents retrospective analysis testing 302 at living Zaporozhye region. presence CMV-specific immunoglobulin G (IgG) M (IgM) antibodies was assessed. In addition, manifestations 56 infants were retrospectively evaluated. A newborn complicated by hepatitis, nephritis, carditis, pneumonia, thrombocytopenia, presented. Statistical processing carried out methods variation statistics. Results. result study immunological profile showed that majority fertile age, residents region seropositive CMV. 3% women, IgM recorded blood, which indicates manifestation an acute form possibility fetus. Prolonged neonatal jaundice dominant symptom 59.3% patients. syndrome perinatal CNS lesion second most frequent these children. order features course, diagnosis selection therapy forms CMV, corresponding disease Conclusions. Most age are immune 5% have primary infection. common with substantial long$term squeal, including sensorineural hearing loss newborns. Diagnosis both polysyndromic lack clear system alertness neonatologists pediatricians guarantee timely Difficulties due low sensitivity pathogen acyclovir need use toxic drug ganciclovir. Timely administration highly anti-CMV-therapy not only saves patient's life, but also improve developmental outcomes. research accordance principles Helsinki Declaration. protocol approved Local Ethics Committee Institutes. informed consent patient obtained conducting studies. No conflict interest declared authors. Key words: infection, newborns, forms, diagnostics, manifestations, treatment.